AMTAGVI™ uses T cells from the patient’s immune system to fight their melanoma1,2

AMTAGVI consists of T cells from a patient's own immune system, which produces a unique therapy for each patient.1

Tumor to treatment process1,2

fpo

T cells are part of the body’s natural response to cancer and are found in tumors.

Close up of a tumor biopsy being placed on a piece of gauze.

AMTAGVI starts with a piece of the patient’s tumor tissue.

Image of a lab where a technician is separating T cells from tumor tissue.

The tumor tissue is shipped to a manufacturing facility, where T cells are isolated.

A close up image of A container filled with amber-colored AMTAGVI IV solution.

T cells are amplified in number to billions,† which are then cryopreserved and shipped to an Authorized Treatment Center (ATC).

CGI microscopic view of AMTAGVI (lifileucel) T cells attacking tumor.

AMTAGVI,‡ made up of billions of individualized T cells, is infused into the patient.

Turnaround time includes 22 days for manufacturing, plus up to 2 weeks for product availability.§

*The specific mechanism of action of AMTAGVI (lifileucel) is unknown.

†A single dose of AMTAGVI contains 7.5 x 109 to 72 x 109 viable cells.1

‡AMTAGVI treatment regimen consists of lymphodepletion followed by AMTAGVI infusion followed by IL-2 (aldesleukin) administration. Full regimen details can be viewed here.1

§Actual turnaround times may vary.1

IL-2, interleukin-2.

GO TO UNMET NEED

More than half of patients progress within 12 months on current 1L checkpoint inhibitor treatments3-5

Learn about the unmet need in
metastatic melanoma

Clinical trial data, including response and durability results

View clinical trial results and
study design

What is AMTAGVI (lifileucel)?

AMTAGVI is a prescription medicine used to treat adults with a type of skin cancer that cannot be removed surgically or has spread to other parts of the body called unresectable or metastatic melanoma.

AMTAGVI is used when your melanoma has not responded or stopped responding to a PD-1 blocking drug either by itself or in a combination, and if your cancer is BRAF mutation positive, a BRAF inhibitor drug with or without a MEK inhibitor drug that has also stopped working.

The approval of AMTAGVI is based on a study that measured response rate. Continued approval for this use may depend on the results of an ongoing study to confirm benefit.

Please see accompanying Full Prescribing Information and Patient Information, including BOXED WARNINGS, for additional Important Safety Information.

Important Safety Information

AMTAGVI is associated with serious and potentially life-threatening or fatal side effects, including treatment-related death, prolonged severe low blood cell counts (cytopenia), serious infections, and cardiopulmonary (heart, lung) and renal (kidney) impairment. Your healthcare provider will monitor you for these side effects during treatment.

What is the most important information that I should know about AMTAGVI?

You will likely be in a hospital prior to and after receiving AMTAGVI.

Before taking AMTAGVI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have any lung, heart, liver or kidney problems
  • Have low blood pressure
  • Have a recent or active infection or other inflammatory conditions including cytomegalovirus (CMV) infection, hepatitis B or C or human immunodeficiency virus (HIV) infection
  • Are pregnant, think you may be pregnant, or plan to become pregnant
  • Are breastfeeding
  • Notice the symptoms of your cancer are getting worse
  • Have had a vaccination in the past 28 days or plan to have one in the next few months
  • Have been taking a blood thinner

Tell your doctor about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive AMTAGVI?

  • AMTAGVI is made from your surgically removed tumor. Tumor derived T cells are grown in a manufacturing center at the end of which they number in the billions of cells.
  • Your tumor tissue is sent to a manufacturing center to make AMTAGVI. It takes about 34 days from the time your tumor tissue is received at the manufacturing center until AMTAGVI is available to be shipped back to your healthcare provider, but the time may vary. Your AMTAGVI will be provided in 1-4 patient-specific infusion bag(s) containing 100 mL to 125 mL of viable (alive) cells per bag.
  • After your AMTAGVI arrives at your treating institution, your healthcare provider will give you lymphodepleting chemotherapy to prepare your body.
  • Approximately 30 to 60 minutes before you are given AMTAGVI, you may be given other medicines including:
    • Medicines for an allergic reaction (anti-histamines)
    • Medicines for fever (such as acetaminophen)
  • Your AMTAGVI will be provided in 1 to 4 infusion bag(s) containing 100 mL to 125 mL of viable cells per bag. When your body is ready for AMTAGVI infusion, your healthcare provider will give AMTAGVI to you by intravenous infusion. This usually takes less than 90 minutes.

After getting AMTAGVI

Beginning 3 to 24 hours after AMTAGVI is given, you may be given up to 6 doses of IL-2 (aldesleukin) every 8 to 12 hours via intravenous infusion. Your doctor may discontinue IL-2 (aldesleukin) infusion any time if you have severe side effects.

You will have to stay in the hospital until you have completed the IL-2 (aldesleukin) treatment and you have recovered from any serious side effects associated with the AMTAGVI treatment.

You should plan to stay within 2 hours of the location where you received your treatment for several weeks after getting AMTAGVI. Your healthcare provider will check to see if your treatment is working and help you with any side effects that occur.

What are the possible side effects of AMTAGVI?

The most common side effects of the AMTAGVI treatment include chills, fever, low white blood cell count (may increase risk of infections), fatigue, low red blood cell count (may cause you to feel tired or weak), fast or irregular heartbeat, rash, low blood pressure, and diarrhea.

These are not all the possible side effects of the AMTAGVI treatment. Talk with your healthcare provider for more information about AMTAGVI. You can ask your healthcare provider for information about AMTAGVI that is written for healthcare professionals.

You may report side effects to Iovance at 1-833-400-46821-833-400-4682, or to the FDA, at 1-800-FDA-10881-800-FDA-1088 or at www.fda.gov/medwatch.

Please see accompanying Full Prescribing Information and Patient Information, including Boxed WARNINGS, for additional Important Safety Information.

 

What is AMTAGVI (lifileucel)?

AMTAGVI is a prescription medicine used to treat adults with a type of skin cancer that cannot be removed surgically or has spread to other parts of the body called unresectable or metastatic melanoma.

AMTAGVI is used when your melanoma has not responded or stopped responding to a PD-1 blocking drug either by itself or in a combination, and if your cancer is BRAF mutation positive, a BRAF inhibitor drug with or without a MEK inhibitor drug that has also stopped working.

The approval of AMTAGVI is based on a study that measured response rate. Continued approval for this use may depend on the results of an ongoing study to confirm benefit.

Please see accompanying Full Prescribing Information and Patient Information, including BOXED WARNINGS, for additional Important Safety Information.

Important Safety Information

AMTAGVI is associated with serious and potentially life-threatening or fatal side effects, including treatment-related death, prolonged severe low blood cell counts (cytopenia), serious infections, and cardiopulmonary (heart, lung) and renal (kidney) impairment. Your healthcare provider will monitor you for these side effects during treatment.

What is the most important information that I should know about AMTAGVI?

You will likely be in a hospital prior to and after receiving AMTAGVI.

Before taking AMTAGVI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have any lung, heart, liver or kidney problems
  • Have low blood pressure
  • Have a recent or active infection or other inflammatory conditions including cytomegalovirus (CMV) infection, hepatitis B or C or human immunodeficiency virus (HIV) infection
  • Are pregnant, think you may be pregnant, or plan to become pregnant
  • Are breastfeeding
  • Notice the symptoms of your cancer are getting worse
  • Have had a vaccination in the past 28 days or plan to have one in the next few months
  • Have been taking a blood thinner

Tell your doctor about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive AMTAGVI?

  • AMTAGVI is made from your surgically removed tumor. Tumor derived T cells are grown in a manufacturing center at the end of which they number in the billions of cells.
  • Your tumor tissue is sent to a manufacturing center to make AMTAGVI. It takes about 34 days from the time your tumor tissue is received at the manufacturing center until AMTAGVI is available to be shipped back to your healthcare provider, but the time may vary. Your AMTAGVI will be provided in 1-4 patient-specific infusion bag(s) containing 100 mL to 125 mL of viable (alive) cells per bag.
  • After your AMTAGVI arrives at your treating institution, your healthcare provider will give you lymphodepleting chemotherapy to prepare your body.
  • Approximately 30 to 60 minutes before you are given AMTAGVI, you may be given other medicines including:
    • Medicines for an allergic reaction (anti-histamines)
    • Medicines for fever (such as acetaminophen)
  • Your AMTAGVI will be provided in 1 to 4 infusion bag(s) containing 100 mL to 125 mL of viable cells per bag. When your body is ready for AMTAGVI infusion, your healthcare provider will give AMTAGVI to you by intravenous infusion. This usually takes less than 90 minutes.

After getting AMTAGVI

Beginning 3 to 24 hours after AMTAGVI is given, you may be given up to 6 doses of IL-2 (aldesleukin) every 8 to 12 hours via intravenous infusion. Your doctor may discontinue IL-2 (aldesleukin) infusion any time if you have severe side effects.

You will have to stay in the hospital until you have completed the IL-2 (aldesleukin) treatment and you have recovered from any serious side effects associated with the AMTAGVI treatment.

You should plan to stay within 2 hours of the location where you received your treatment for several weeks after getting AMTAGVI. Your healthcare provider will check to see if your treatment is working and help you with any side effects that occur.

What are the possible side effects of AMTAGVI?

The most common side effects of the AMTAGVI treatment include chills, fever, low white blood cell count (may increase risk of infections), fatigue, low red blood cell count (may cause you to feel tired or weak), fast or irregular heartbeat, rash, low blood pressure, and diarrhea.

These are not all the possible side effects of the AMTAGVI treatment. Talk with your healthcare provider for more information about AMTAGVI. You can ask your healthcare provider for information about AMTAGVI that is written for healthcare professionals.

You may report side effects to Iovance at 1-833-400-46821-833-400-4682, or to the FDA, at 1-800-FDA-10881-800-FDA-1088 or at www.fda.gov/medwatch.

Please see accompanying Full Prescribing Information and Patient Information, including Boxed WARNINGS, for additional Important Safety Information.